| 摘要 |
Peptide polyhydroxyalkylamides of formula (I) and their salts are new; where A = R1R6N-CHR5-CO-, R1R7CH-CHR5-CO- or R1O-CHR5-CO-; R1 = R'1 or R'1W; R'1 = (a) 3-8C cycloalkyl, CONH2, OCH2COOH, NH2, etc. (b) H, OH or 1-4C alkoxy, (c) 1-18C alkyl, quanidino, phenyl(1-4C)alkoxy, etc. (d) 6-14C aryl, (6-14C)aryl(1-4C)alkyl, etc. (e) Het or Het(1-4C)alkyl, where Het is an opt. benzo-fused 5- to 7-membered heterocyclic ring contg. 1 or 2 of N, O, S, No, etc. (f) NR8R9; Het or Het(1-4C)alkyl, or NR8R9 is a mono- or bicyclic 5- to 12-membered ring system opt. contg. 1 or 2 more N atoms, an S atom or an O atom, opt. substd. by 1-4C alkyl; W = CO, CS, OSO, SO2, SO, NHSO2, NHCO, CHOH or NOH; n = 2-10. |
