Treatment of dysfunctional vascular endothelium using activated protein C

摘要

A pharmaceutical composition comprising activated protein C activity is used to treat subjects for permeability and coagulopathic dysfunctions of vascular endothelial cells in response to an inflammatory stimulus. The composition may be used to prevent or to reverse these pathological events. Further, the composition is used to prevent elevated plasma levels of tumor necrosis factor, an inflammatory mediator which participates in the chain of events which produce the dysfunctional responses.