发明名称 |
FREMGANGSMAADE TIL FREMSTILLING AF 3',4'-DIDEOXYKANAMYCIN B OG BESKYTTEDE KANAMYCIN B-DERIVATER TIL ANVENDELSE SOM UDGANGSMATERIALE VED FREMGANGSMAADEN |
摘要 |
<p>New routes are provided for the synthesis of 3',4'-dideoxykanamycin B which is effective in inhibiting kanamycin-resistant organisms from kanamycin B through new intermediate, of which a fundamental process comprises a new reaction of a 3',4'-epoxy derivative of amino- and hydroxyl-protected kanamycin B with a xanthate to form a corresponding 3',4'-dideoxy-3'-eno derivative followed by removal of the amino- and hydroxyl-protecting groups thereof and by hydrogenation of the resulting 3',4'-dideoxy-3'-eno-kanamycin B. A 3',4'-episulfide derivative corresponding to the 3',4'-epoxy derivative which is formed as second product in the reaction of 3',4'-epoxy derivative with xanthate is also used as intermediate for the preparation of 3',4'-dideoxykanamycin B.</p> |
申请公布号 |
DK159788(C) |
申请公布日期 |
1991.04.22 |
申请号 |
DK19760005541 |
申请日期 |
1976.12.09 |
申请人 |
ZAIDAN HOJIN BISEIBUTSU KAGAKU KENKYU KAI |
发明人 |
UMEZAWA, HAMAO;UMEZAWA, SUMIO;SEKI, SHIGEO;FUKATSU, SHUNZO;YASUDA, SHUNTARO |
分类号 |
C07H15/236;(IPC1-7):C07H15/234 |
主分类号 |
C07H15/236 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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