| 摘要 |
PURPOSE: To obtain a pharmaceutical composition for topical treatments, containing a sucralfate humid gel, capable of contributing its bioadhesiveness to effectively protect inflammatory sites or ulcerative sites and persistently act the therapeutic medicine on the diseased sites. CONSTITUTION: Powdery solid sucralfate having an average particle diameter of <60μm, a specific surface area of >=200m<2> /g, and a water content of 20-85% is dissolved in an aqueous hydrochloric acid or sulfuric acid solution, and subsequently gradually mixed with an aqueous sodium hydroxide solution to adjust the pH of the solution to 4-4.5. The produced gel is washed with water and subsequently centrifuged to obtain the humid gel. The humid gel is advantageously used as a carrier or holder for active ingredients used in therapeutic medicine prescriptions or cosmetic prescriptions, and is compounded in an amount of 5-30wt.% in the prescriptions. The humid gel expresses its bioadhesive power or adhesive power to biological tissues even at a pH of >=4, and is not affected by the presence of a gastric juice.
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