HIV-RELATED EPITOPES FOR DIAGNOSIS AND IMMUNOPROTECTION

摘要

Two epitopes of the envelope glycoprotein (gp120) of Human Immunodeficiency Viruses (HIV-I related viruses) provide immunoprotection and are useful serological markers for protective antibodies. One epitope (448C) is located between amino acid residue 448 and the C-terminus of gp120. The other epitope (KD) is located between amino acids 42 and 129. Polypeptides containing one or both of these epitopes, but substantially lacking certain other interfering epitopes, are useful for immunoassays to predict the course of HIV-1 related disease and to generate protective antibodies (by active or passive immunization).