PROCESS FOR THE PREPARATION OF PENICILLIN DERIVATIVES

摘要

A process for the preparation of alpha -carboxy, 6, alpha -methoxy penicillin derivatives by the enzymatic hydrolysis of an esterified derivative. The process is for the preparation of a compound of formula (I): (I) wherein R represents phenyl or 2- or 3-thienyl, which process comprises subjecting a compound of formula (IV): (IV) wherein R1 is an ester-forming radical, to the action of the enzyme alpha -chymotrypsin or an esterase-producing strain of Streptomyces sp.