发明名称 PROLONGED RELEASE OF BIOLOGICALLY ACTIVE SOMATOTROPINS
摘要 <p>Non-aq. compsn. comprises at least 10wt.% of a biologically active polypeptide (I) and, as a continuous phase of the compsn., a biocompatible oil (II). Also claimed is a non-aq. compsn. of 15-40wt.% of a bovine somatotropin (Ia) chemically associated with zinc, 2-5wt.% of an aluminium mono- or di-stearate (IIIa) and, as a continuous phase of the compsn., a biocompatible vegetable oil. (Ia) has a particulate median vol. dia. of no greater than 5 microns and is present in a wt. ratio to the stearate of at least about 3. (Ia) chemically associated with non-toxic polyvalent metal is also new, pref. 0.3-2wt.% zinc.</p>
申请公布号 EP0177478(B1) 申请公布日期 1991.04.17
申请号 EP19850870135 申请日期 1985.10.03
申请人 MONSANTO COMPANY 发明人 MITCHELL, JAMES WILLIAM
分类号 A61K9/08;A61K9/00;A61K38/16;A61K38/27;A61K47/00;A61K47/12;A61K47/44 主分类号 A61K9/08
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