发明名称 |
Solubilization of lactam and chlorhexidine in water |
摘要 |
Solubility of chlorhexidine free base and hydrocarbon substituted lactams in water is substantially enhanced by forming an aqueous solution of a complex of chlorhexidine free base and lactam. This is preferably done by dissolving chlorhexidine free base in lactam and then mixing the resulting solution with water. The resulting aqueous solution contains between about 1 and about 25 wt % of a complex of lactam and chlorhexidine with chlorhexidine being present in amounts between about 0.08 and about 0.25 wt % based on lactam. Lactam used is defined by the formula <IMAGE> wherein n is an integer having a value of from 1 to 3 and R is a linear alkyl radical containing from 10 to 14 carbon atoms.
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申请公布号 |
US5008038(A) |
申请公布日期 |
1991.04.16 |
申请号 |
US19890419176 |
申请日期 |
1989.10.10 |
申请人 |
GAF CHEMICALS CORPORATION |
发明人 |
MERIANOS, JOHN J.;LOGIN, ROBERT B. |
分类号 |
A61K31/155;A61K31/40;A61K47/22 |
主分类号 |
A61K31/155 |
代理机构 |
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地址 |
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