FOERFARANDE FOER FRAMSTAELLNING AV BIOLOGISKT AKTIVA HEPTAPEPTIDER.

摘要

There are provided peptides of the formula X-Val-Pro-Leu-Gly-Trp-A-Y wherein X represents a hydrogen atom or a terminal nitrogen protecting group, A represents a neutral L- alpha -amino acid residue and Y represents OH, NH2 or a group of the formula OR, NHR, NR2 or NHNHR' wherein R represents a C1-C11 alkyl group optionally substituted, a C7-C14 aralkyl or a phenyl group and R' represents H, any of the groups which R may represent or a protecting group. Pharmaceutically or veterinarily acceptable salt of these peptides are also provided, as are pharmaceutical or veterinary compositions containing peptides or their salts. The peptides which can be prepared by classical solution synthesis, display useful activity on the central nervous system and are active as growth promotors.