| 摘要 |
A chemorepellant compound is disclosed having a general formula where R1 is H or an alkyl group in the range C1 to C6, and R2 is H or an appropriate hydroxyl protecting group, and pharmaceutically acceptable salts and esters thereof. A preferred form of the compound where R1 is hydrogen and R2 is hydrogen is made by incubating linoleic acid with soyabean lipoxygenase or with cytosol associated endothelial cell derived lipoxygenase. The chemorepellant compound can be bound to a prosthetic surface via an intermediate linking species such as a protein and studies have shown that platelet adhesion onto in the vicinity of a thrombogenic surface is greatly reduced in comparison to non-chemorepellant coated surfaces. |
