发明名称 |
Di- or tripeptide renin inhibitors containing lactam conformational restriction in achpa |
摘要 |
Enzyme di- or tripeptides of the formula: <IMAGE> and analogs thereof which inhibit renin and are useful for treating various forms of renin-associated hypertension, hyperaldosteronism and congestive heart failure; compositions containing these renin-inhibitory peptides, optionally with other antihypertensive agents; and methods of treating hypertension, hyperaldosteronism or congestive heart failure or of establishing renin as a causative factor in these problems which employ these novel peptides.
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申请公布号 |
US5006511(A) |
申请公布日期 |
1991.04.09 |
申请号 |
US19880237648 |
申请日期 |
1988.08.26 |
申请人 |
MERCK & CO., INC. |
发明人 |
GREENLEE, WILLIAM J.;VEBER, DANIEL F.;WILLIAMS, PETER D. |
分类号 |
C07D233/54;C07D403/12;C07K5/02 |
主分类号 |
C07D233/54 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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