发明名称 |
TOPICAL ANTIINFLAMMATORY COMPOSITIONS WITH MINIMAL SYSTEMIC ABSORPTION |
摘要 |
Topical polyethylene glycol based formulations for the delivery of 2-substituted-1-naphthols and indoles and particularly, 2-phenylmethyl-1-naphthol are provided. Said topical formulations exert excellent localized antiinflammatory activity while demonstrating low levels of skin penetration in vitro and in vivo thereby reducing unwanted side effects and reducing systemic toxicity associated with the active drug compounds. |
申请公布号 |
AU6289990(A) |
申请公布日期 |
1991.04.08 |
申请号 |
AU19900062899 |
申请日期 |
1990.08.20 |
申请人 |
E.I. DU PONT DE NEMOURS AND COMPANY |
发明人 |
BRUCE JEFFREY AUNGST |
分类号 |
A61K9/06;A61K9/00;A61K31/015;A61K31/05;A61K31/085;A61K31/135;A61K31/165;A61K31/18;A61K31/19;A61K31/22;A61K31/40;A61K31/66;A61K31/665;A61K31/67;A61K31/675;A61K47/10;A61K47/34;A61P29/00;C07C39/14;C07C39/38;C07C43/253;C07C49/835;C07C49/84;C07C65/17;C07C69/157;C07C69/732;C07C69/734;C07C69/738;C07C69/94;C07C229/40;C07C233/23;C07C235/40;C07C247/02;C07C255/01;C07C311/07;C07C317/20;C07C323/17;C07F9/40;C07F9/572 |
主分类号 |
A61K9/06 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|