MEDICINAL AEROSOL FORMULATIONS

摘要

A self-propelling, powder dispensing aerosol composition comprising at least 0.0001 % by weight of a finely-divided solid medicament coated with a non-perfluorinated surface-active dispersing agent which constitutes at least 0.0001 % by weight of the coated solid material, and suspended in an aerosol propellant in which the non-perfluorinated surface-active dispersing agent is substantially insoluble. Non-fluorinated surfactants which are insoluble in propellants, such as Propellant 134a, may be used to prepare stable dispersions of powdered medicament provided the medicament is pre-coated with the surfactant prior to admixture with propellant.