| 摘要 |
<p>A method for isolating a cDNA specific for the human ryanodine receptor is disclosed. The gene is associated with malignant hyperthermia, a hypermetabolic syndrome triggered primarily by inhalation anaesthetics, but also present in animals, such as pigs, as induced by stress. The cDNA can be cloned and expressed in a recombinant plasmid or phage. The cDNA, or fragments thereof, is used as diagnostic probes for individuals or animals at risk for malignant hyperthermia using restriction fragment length polymorphism analysis.</p> |
