1,4-DIHYDROPYRIDINE.

摘要

The invention concerns compounds of formula (I) or salts thereof; wherein Ar is an optionally substituted aryl radical; R represents hydrogen or an optionally substituted alkyl or aralkyl group; R1 and R2 are the same or different and are selected from hydrogen and saturated or unsaturated, cyclic or acyclic aliphatic hydrocarbon residues optionally substituted by one or more groups selected from halogen, OH, carboxy, CN, alkoxy, alkylthio, aryloxy, alkoxycarbonyl, amino, substituted amino, and optionally substituted aryl; A represents a group of formula -XR3 wherein X is (i) a group of formula -(CHR6)p-Y-(CHR7)q-or (ii) a group of formula -(CHR6)r-O-(CHR7)q in which formulae: Y represents -S+13, NR8 or a direct bond, p and q each represent 0, 1 or 2 providing that p and q do not both represent 0, 1 or 2 and the other is zero; R6, R7 and R8 independently represent hydrogen or lower alkyl, and R3 is an optionally substituted nitrogen ring heteroaryl radical optionally containing other ring heteroatoms selected from oxygen, nitrogen or sulphur; B represents hydrogen, carboxyl, lower alkoxycarbonyl, lower alkyl optionally substituted by amino, lower alkoxy, lower alkoxycarbonyl or carboxyl, or amino optionally substituted by one or two lower alkyl groups, which compounds possess anithypertensive and antithrombotic activity.