| 摘要 |
A novel controlled release composition which provides a precisely regulated non-initial burst release of an active substance at a predetermined time, the composition being adapted to controlled delivery of at least one active substance into an aqueous phase by erosion at a substantially constant rate of a surface or surfaces of the composition, the composition comprising at least one layer of A) comprising at least one active substance, and at least one of the layers B) and C), layer B) comprising a matrix of a substantially water soluble crystalline polymer and layer C) comprising at least one active substance substantially homogeneously dispersed in a substantially water soluble crystalline polymer matrix. The composition of the invention is especially suitable for use in, for example, the treatment of rheumatoid arthritis or related disorders with non-steroidal anti-inflammatory agents. The composition enables release of the correct amount of drug at a predetermined time, e.g. in the morning before waking, at which time untreated morning stiffness caused by a dramatic change in posture leads to an intense feeling of pain for arthritis sufferers. |
