PROCESS FOR PREPARING DL-SERINE AND PROCESS FOR SEPARATION AND PURIFICATION OF THE SAME

摘要

Disclosed is a process for preparing DL-serine, which comprises synthesizing DL-serine according to Strecker reaction with use of a cyan compound, ammonium chloride, ammonia and a reaction substrate comprising glycol aldehyde, wherein the Strecker reaction is carried out under the reaction conditions of: molar ratios of the starting materials of: glycol aldehyde/cyan compound: more than 1.0 and not more than 1.50 ammonium chloride/glycol aldehyde: more than 1.0 and not more than 2.0 ammonium/cyan compound: 1.0 to 7.0 reaction temperature: 20 to 80 DEG C reaction time: 15 to 120 minutes, and the reaction product obtained is hydrolyzed. Disclosed is also a process for separation and purification of DL-serine produced in the above by subjecting the aqueous solution containing DL-serine alkali salt obtained to ion exclusion chromatography by use of a strongly acidic cation exchange resin, neutralizing the fractionated DL-serine fractions to near the isoelectric point of DL-serine and subjecting the neutralized product to ion exclusion chromatography with a strongly acidic cation exchange resin.