NEW ESTER OF ALCOHOL DERIVATIVE OF 19-NOLSTEROID AND ORGANIC ACID AND THEIR SALTS, THEIR MANUFACTURING METHOD AND INTERMEDIATES OF THIS METHOD, USE OF THESE CHEMICALS AS DRUGS AND COMPOUNDS CONTAINING THE CHEMICALS

摘要

NEW MATERIAL: A compound of formula I [R1 is a 1-8C aliphatic hydrocarbon group; R2 and R3 are each H or a 1-4C alkyl; G is a hydrocarbon group which contains 1-18 carbon atoms and optionally one or more heteroatoms and is bonded to a steroid nucleus by a carbon atom; X is XA or XS; XA is a 1-8C alkyl, a 7-15C arylalkyl or a 1-8C acyl; Xa is CO-A-Z (A is a 1-6C aliphatic group or an aromatic group; Z is COOH or SO2 H); Y is YA=B-O-CO-A-Z (B is a 1-8C aliphatic group) when X is Xa and Y is Ya (Ya is C≡CR4 , CH=CHR4 or CH2 -CH2 R4 ; R4 is H, a halogen, a 1-6C alkyl, etc.]. USE: A medicine having progesterone-like or anti-progesterone-like activity, androgen activity, anti-androgen activity, anti-glucocorticoid activity, glucocorticoid activity, anti-proliferation characteristics, etc. PROCESS: For example, a compound of formula II is reacted with a compound of formula III to give a compound of formula I in which X is XA and Y is YA.