Chromene or thiochromene derivatives, process for preparing the same, intermediate therefor, pharmaceutical compositions containing said derivatives and the use of said derivatives.

摘要

A chromene or thiochromene derivative of the formula: wherein A is oxygen or sulfur atom, R<1> is a halogenophenyl, R<2> and R<3> are the same or different and are each a lower alkyl or R<2> and R<3> are combined together to form -(CH2)n- in which n is an integer of 4 to 6, or a pharmaceutically acceptable ester, amide, lactone or salt thereof, which has excellent HMG-CoA reductase inhibitory activity and is useful for prophylaxis and treatment of hyperlipidemic diseases, a process for preparing said compound and an intermediate compound used for preparing said compound. Further, a pharmaceutical composition containing the above mentioned chromene or thiochromene derivatives is disclosed.