Use of protease inhibitors as antiexudative, antiphlogistic and antimicrobial agents.

摘要

A medcamentous form with antiexudation, antiphlogistic and antimicrobial effects in an aqueous or ointment base, suitable above all as an ophthalmologic, otolaryngologic, or dermatologic drug, which contains inhibitors or proteases, as are aprotinin, soyabean trypsine inhibitor, and elastatinal, either single or in a combination, in the amount of 0.1 mg to 20 mg per 1 ml of physiological saline or buffer solution, which is preferably ionically balanced and has pH 6.5 to 7.5, pr per 1 g of ointment base. The medicamentous form may further contain 0.05 to 1.5 wt.-% of steroidal antiphlogistics, for example, dexamethasone, and/or 0.05 to 5 wt.% of nonsteroidal antiphlogistics, for example, indomethacin, and/or 0.2 to 1 wt.-% of antibiotics suppressing the growth of microbes, as are, for example, neomycin, bacitracin, chloramphenicol, tetracycline.