发明名称 |
6-and/or 7-substituted -1,2,3,4,4A,9B-hexahydro-8-hydroxydibenzofuran-3-ols as inhibitors of leukotriene biosynthesis. |
摘要 |
<p>Positions 7-and/or 6-substituted 1,2,3,4,4a,9b-Hexahydro-8-hydroxydibenzofuran-3-ols and analogs of that general structure are described. These compounds are found to be potent inhibitors of 5-lipoxygenase, an enzyme crucial to the biosynthesis of leukotrienes and useful in the treatment of a variety of inflammatory conditions.</p> |
申请公布号 |
EP0420571(A2) |
申请公布日期 |
1991.04.03 |
申请号 |
EP19900310478 |
申请日期 |
1990.09.25 |
申请人 |
MERCK & CO. INC. |
发明人 |
RUPPRECHT, KATHLEEN;BOGER, JOSHUA S. |
分类号 |
C07D307/77;C07D307/91;A61K31/34;A61K31/343;A61P9/00;A61P11/00;A61P29/00;A61P37/08 |
主分类号 |
C07D307/77 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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