| 摘要 |
<p>The derivatives of glycoside bioflavonoids having general formula: <CHEM> wherein P represents the flavonic residue containing phenolic hydroxyls and R min represents H, (CO-R-CO-O-N)n , in which X is selected among H, the cation of a pharmaceutically acceptable base and the radicals of polyoxyethylenglycols, polyoxypropylenglycols and their monomethylethers and R is an alkyl or aryl radical of a dicarboxylic acid, are water soluble and biodecomposable, maintaining at least the same therapeutical activity of the starting bioflavonoids. For their preparation the starting glycoside is reacted with the anhydride of the dicarboxylic acid , the resulting ether carboxylic derivative is reacted with a pharmaceutically acceptable base, for instance an alkali methal hydroxyde, carbonate or bicarbonate, or with polyoxyethylenglycol, polyoxypropylenglycol or their monomethylethers.</p> |
