发明名称 Process for obtaining 1-aryloxy-3-nitroamino-2-propanols
摘要 Process for obtaining 1-aryloxy-3-nitroamino-2-propanols of formula I where: Ar represents a phenyl or naphthyl radical; R1 and R2, which may be the same or different, can occupy any substitution position relative to the aromatic nucleus and represent hydrogen or a straight or branched alkyl chain of 1 to 4 carbon atoms; and R3 represents a straight or branched alkyl chain of 1 to 4 carbon atoms, based on the reaction of a 1-aryloxy-3- amino-2-propanol of formula <IMAGE> in which Ar, R1, R2 and R3 have the meanings indicated above, with a member of the group comprising thionyl nitrate chloride and n-nitro collidine tetrafluorate. These compounds are of pharmacological use, particularly for cardiovascular activity. <IMAGE>
申请公布号 ES2018407(A6) 申请公布日期 1991.04.01
申请号 ES19890003562 申请日期 1989.10.23
申请人 PRODESFARMA S.A. 发明人 VENTOSA RULL LEONOR
分类号 A61K31/04;A61K31/045;C07C31/10;C07C243/02;(IPC1-7):C07C243/02 主分类号 A61K31/04
代理机构 代理人
主权项
地址