摘要 |
Benzanilide derivatives of the formula: I wherein R1 is alkyl optionally containing double or triple bonds, and optionally interrupted by one or more hetero atoms; R2 is hydrogen, methyl, or ethyl; R3 is halogen, alkyl, -OY, -SOnY, or dimethylamino; R4 and R5 are hydrogen, alkyl or -(CH2)m-Z, wherein: (i) Z is -OCH3, -SOqCH3, -N(CH3)2 or alkanoylamino, and m is 2, 3 or 4; or (ii) Z is heterocyclyl and m is 0, 1, 2, 3, or 4; X is oxygen, -OCH2-, -SOp-, -SOpCH2- or -NR6-; R6 is hydrogen, methyl, ethyl, or acyl; Y is alkyl; and n, p and q are each 0, 1, or 2; are useful as anti-atherosclerotic agents.
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