发明名称 |
PROCESS FOR PRODUCING 20-ISOCYANO-20-(ALKYL- OR ARYLSULFONYL)- DELTA ABOVE 16-STEROIDS |
摘要 |
The invention relates to a new process for the introduction into steroids of a 17-side chain containing a 20-keto group under the simultaneous formation of an unsaturated bond between C16 and C17 by reaction of 17-(isocyano-sulfonylmethylene)-steroids with an alkylating agent to 20-isocyano-20-sulfonyl-delta<1><6>-steroids, followed by hydrolysis of these latter compounds to 20-keto-delta<1><6>-steroids. The invention also relates to the intermediate compounds which are formed in this process, i.e. 20-isocyano-20-sulfonyl-delta<1><6>-steroids and to the ultimately formed 20-keto-delta<1><6>-steroids, as far as these latter compounds are new. |
申请公布号 |
HU202552(B) |
申请公布日期 |
1991.03.28 |
申请号 |
HU19870004318 |
申请日期 |
1984.04.27 |
申请人 |
GIST-BROCADES N.V.,NL |
发明人 |
VAN LEUSEN,ALBERT MATTHEUS,NL;VAN LEUSEN,ADRIAAN MARINUS,NL |
分类号 |
B01J31/02;C07B61/00;C07J13/00;C07J41/00;C07J75/00 |
主分类号 |
B01J31/02 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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