| 发明名称 |
PROCESS FOR PRODUCING 1-AMINO-METHYL-1-CYCLOHEXAN-ACETIC ACID |
| 摘要 |
<p>The invention relates to a novel embodiment of the Michael addition in the preparation of aminomethyl-1-cyclohexaneacetic acid (gabapentin), starting from cyclohexanone. By the use of KOH in the first reaction step, reaction with nitromethane in DMSO with alkali metal carbonate catalysis and reduction of the introduced nitro group at elevated temperature, the yield is raised and the safety of the preparation process is substantially increased.</p> |
| 申请公布号 |
HUT54623(A) |
申请公布日期 |
1991.03.28 |
| 申请号 |
HU19900005332 |
申请日期 |
1990.08.24 |
| 申请人 |
GOEDECKE AG.,DE |
发明人 |
GEIBEL,WOLFRAM,DE;HARTENSTEIN,JOHANNES,DE;HERRMANN,WOLFGANG,DE;WITZKE,JOACHIM,DE |
| 分类号 |
B01J27/232;C07B61/00;C07C227/06;C07C227/12;C07C227/18;C07C227/20;C07C227/22;C07C229/28;(IPC1-7):C07C229/28 |
主分类号 |
B01J27/232 |
| 代理机构 |
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