| 摘要 |
A process for 4-halomethylazetidin-2-ones is provided which comprises mixing in an inert solvent a positive halogen reagent in the presence of a weak base with a .beta.,.gamma.-unsaturated O-acylhydroxamate of the formula wherein R is protected amino, lower alkyl or phenyl substituted lower alkyl, R2 is a substituent such as lower alkyl which may be substituted by formyl, hydroxy, halogen, etc., and R1 is alkoxy, benzyloxy, etc. When R is a protected amino group, the-process provides cis-4-halomethylazetidin-2-ones, while when R is alkyl or phenylalkyl, the trans isomer is obtained. The 4-halo-methylazetidinones are useful intermediates for known antibiotic compounds. |
