| 摘要 |
PCT No. PCT/US88/02429 Sec. 371 Date Jan. 30, 1990 Sec. 102(e) Date Jan. 30, 1990 PCT Filed Jul. 22, 1988 PCT Pub. No. WO89/01483 PCT Pub. Date Feb. 23, 1989.The invention involves a two step chemical transformation of a steroidal 17-cyanohydrin (II) <IMAGE> (II) to a 17 alpha -hydroxy-21-halo-20-keto steroid (IV) <IMAGE> (IV) intermediate which can readily be converted to pharmaceutically useful corticoids.
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