TRANS 2,3-DISUBSTITUTED-2,3-DIHYDRO-5-HYDROXYBENZOFURANS AS INHIBITORS OF LEUKOTRIENE BIOSYNTHESIS

摘要

90/VJC29 17969 TITLE OF THE INVENTION TRANS 2,3-DISUBSTITUTED-2,3-DIHYDRO-5-HYDROXY-BENZOFURANS AS INHIBITORS OF LEUKOTRIENE BIOSYNTHESIS The novel trans-2,3-disubstituted-2,3-dihydro-5-hydroxybenzofurans are described. The synthesis involves an intramolecular Michael addition to yield the thermodynamic trans isomer. The compounds were found to be inhibitors of 5-lipoxygenase, an enzyme crucial to the biosynthesis of leukotrienes and useful for the treatment of various inflammatory diseases.