HETEROCYCLIC HYDRAZIDE DERIVATIVES OF MONOCYCLIC BETA-LACTAM ANTIBIOTICS

摘要

GC272 HETEROCYCLIC HYDRAZIDE DERIVATIVES OF MONOCYCLIC BETA-LACTAM ANTIBIOTICS Antibacterial activity has been found in compounds of the formula and pharmaceutically acceptable salts thereof, wherein: A is a bond or alkyl; Q completes a 5- or 6-membered saturated or aromatic heterocyclic ring optionally comprising up to two heteroatoms independently selected from N, NR5, S, O and carbonyl; Y is amino, hydroxy, carboxyl (provided that the heterocyclic ring is not guinoxaline or quinoline), halogen, carboxamide, or nitrile; M? is hydrogen or a cation; and the remaining symbols are as defined in the specification.