| 摘要 |
NEW MATERIAL:The compound of formula (R1 is 0 or tetraacetylglucopyranosyloxyl). EXAMPLE:Methyl (1S,4aS,7aS)-7-acetoxymethyl)-1-(2,3,4,6-tetra-O-acetyl-beta-D- glucopyranosyloxy)-1,4a,5,7a-tetrahydrocyclopenta-[c]pyran-4-carboxylate. USE:It has aldose reductase inhibiting action and is useful as a remedy for complication of diabetes. PREPARATION:Geniposide or genipin existing in KUTINASHI (fruit of Gardenia jasminoides) is used as a raw material and subjected to a proper combination of acetylation, deacetylation, methylation, hydrolysis, oxidation, reduction, introduction of protecting group, etc., according to the kind of the objective substance. |
