CONTROLLED RELEASE PHARMACEUTICAL COMPOSITIONS FROM SPHERICAL GRANULES IN TABLETTED ORAL DOSAGE UNIT FORM

摘要

CONTROLLED RELEASE PHARMACEUTICAL COMPOSITIONS FROM SPHERICAL GRANULES IN TABLETTED ORAL DOSAGE UNIT FORM A controlled release pharmaceutical composition in oral dosage unit form comprising a tablet comprising a therapeutically effective number of active spherical granules comprising an effective amount of active medicament, a pharmaceutically acceptable normally solid diluent adapted to form a diffusible matrix for the active medicament and an optional pharmaceutically acceptable excipient; and a number of compressible spherical granules comprising a mono- or disaccharide, an optional pharmaceutical acceptable normally solid diluent adapted to form a diffusible matrix, an optional active medicament and/or an optional pharmaceutically acceptable excipient wherein the average comprehensive yield of the compressible spherical granules is less than the average compressible yield of the active spherical granules is provided. A method for the preparation and for the administration of the above defined composition is provided as well.