PROCESS FOR THE PREPARATION OF A NANOEMULSION OF OILPARTICLES IN AN AQUEOUS PHASE

摘要

An aqueous phase, an oil of a triglyceride or fatty acid ester, and, per part by weight of oil 0.05 to 0.4 part by weight of an amphoteric emulsifier are mixed together and processed in a high-pressure homogenizer into a nanoemulsion of less than 200 nm sized oil particles. The emulsifier, exhibiting in the aqueous phase a lamellar liquid-crystalline structure, is preferably a glycerophosphatide of the formula: wherein, R1 and R2 mean acyloxy and/or alkyl or alkenyl ether. R3 is a tri-lower-alkyl ammonio or amino-substituted lower alkyl. The resultant nanoemulsion is stable for a period of several months and does not contain any toxic emulsifier materials. Therefore, it can be advantageously utilized as a vehicle for active agents, for example medicines and/or cosmetic ingredients.