PROCESS FOR THE CHEMICAL RESOLUTION OF 5-ALKOXY-SUBSTITUTED (+)-1,3-DIMETHYLOXINDOLYETHYLAMINES

摘要

- 1 - HOE 89/5 047 Process for the chemical resolution of 5-alkoxy-substituted (?)-1,3-dimethyloxindolylethylamines A process for chemically resolving a mixture of enantiomers of primary amines, such as enantiomers of 1,3-dimethyl-5-methoxyoxindolylethylamine, provides one of the enantiomers in the form of a tartaric acid salt. In carrying out the process, an enantiomeric mixture is contacted with a chiral acid in an amount sufficient to preferentially precipitate a salt of the chiral acid and one of the enantiomers. The resulting precipitate can then be recovered. The chiral acid is selected from the group consisting of dibenzoyl-D-tartaric acid, dibenzoyl-L-tartaric acid, ditoluoyl-D-tartaric acid, and ditoluoyl-L-tartaric acid. The precipitates can be used in the synthesis of stereospecific forms of physostigmine.