PRODUCTION OF 9-(BETA-D-ERYTHRO-OXETANOSYL) COMPOUND

摘要

PURPOSE:To obtain the subject compound useful as an antiviral agent by reacting a specific oxetanosine derivative with a carboxylic acid salt and removing protecting group, etc., from the reaction product. CONSTITUTION:The objective compound of formula V can be produced by reacting an oxetanosine derivative of formula I [P1 is protecting group; R1 is (substituted) lower alkylsulfonyl or (substituted) arylsulfonyl; B is purine base residue having protected functional group] [e.g. the compound of formula II (Bz is benzoyl; Tf is trifluoromethanesulfonyl)] with a carboxylic acid salt (e.g. sodium benzoate) and removing the protecting group and group R2 from the resultant compound of formula III (R2 is organic carbonyl) (e.g. the compound of formula IV).