发明名称 |
Optical resolution of DL-3-acylthio-2-methylpropanoic acid |
摘要 |
An optically active amine compound and a method for preparing same are provided which compound has the structure <IMAGE> in the form of its R-(+) enantiomer or S-(-) enantiomer, wherein R and R1 are independently H, lower alkyl or halogen, R2 is H or lower alkyl and R3 is lower alkyl, the optically active amine is useful in the optical resolution of DL-3-acylthio-2-methylpropanoic acid wherein acyl is acetyl or benzoyl. The optically active D-(+)-3-acylthio-2-methylpropanoic acids are used as intermediated for preparing antihypertensive agents, such as captopril.
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申请公布号 |
US5001251(A) |
申请公布日期 |
1991.03.19 |
申请号 |
US19880144159 |
申请日期 |
1988.01.15 |
申请人 |
E. R. SQUIBB & SONS, INC. |
发明人 |
MACMANUS, PATRICK A.;WALSH, PETER;KILBANE, ADRIAN J. |
分类号 |
C07C209/08;C07C211/30;C07C327/32 |
主分类号 |
C07C209/08 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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