N-ARYL-N-(4-PIPERIDINYL)AMIDES AND PHARMACEUTICAL COMPOSITIONS AND METHODS EMPLOYING SUCH COMPOUNDS

摘要

Compounds arc disclosed of the formula <IMG> optically active isomeric forms thereof, and/or pharmaceutically acceptable acid addition salts thereof, in which formula: R is selected from the group consisting of phenyl and substituted phenyl wherein the substituents are selected from halogen, cyano, lower-alkoxy, lower-alkyl, lower-alkylenedioxy, halogenated lower-alkyl, loweralkylthio, or combinations thereof; R1 is selected from a furanyl group, a thienyl group or a group of the formula <IMG> wherein R5 is selected from lower-alkyl, lower-cycloalkyl, halogenated lower-alkyl, phenyl, or phenyl lower-alkyl, and wherein each R6 is independently selected from hydrogen, lower-cycloalkyl or lower-alkyl: P2 is selected from the group consisting of phenyl-lower-alkyl, loweralkyl, lower-alkenyl, loher-alkynyl, halogenated loweralkyl, (cycloalkyl)alkyl, thienyl lower-alkyl, thiazolyl lower-alkyl which can be substituted in the 4-position with a methyl group, (4,5-dihydro-5-oxo-1H-tetrazol-1-yl) lower-alkyl which can be substituted in the 4-position with a group selected from lower-alkyl, lower cycloalkyl, aryl or aryl lower-alkyl, and substituted phenyl loweralkyl in which the substituents on the phenyl ring are selected from halogen, cyano, lower-alkoxy, lower-alkyl, lower-alkylenedioxy, halogenated lower-alkyl, loweralkylthio or combinations thereof; R3 is selected from a group consisting of hydrogen, methoxymethyl, and a carboxylate radical represented by the formula <IMG> wherein R10 is selected from the group consisting of lower-alkyl, aryl-lower-alkyl, lower-alkoxy-lower-alkyl, and aryloxy-lower-alkyl; and R4 is selected from hydrogen or methyl. Analgesic compositions containing these compounds and methods of using such compounds are also disclosed.