发明名称 N-aminobutyl-n-phenylarylamide compounds and their application in therapy
摘要 A compound of formula (I) <IMAGE> (I) in which: X denotes hydrogen, a halogen, a trifluoromethyl group, a C1-C4 alkyl group or a C1-C4 alkoxy group; R1 denotes a linear or branched C2-C8 alkyl group, a C3-C5 cycloalkyl group or a cycloalkylmethyl group in which the cycloalkyl moiety has from 3 to 5 carbon atoms; R2 denotes hydrogen or a C1-C4 alkyl group; R3 denotes hydrogen, a C1-C4 alkyl group, an optionally substituted phenylalkyl group or a pyridylalkyl group; or R2 and R3 denote, together with the nitrogen to which they are attached, a pyrrolidinyl, piperidyl, morpholinyl, perhydrothiazinyl, piperazinyl or 4-methylpiperazinyl ring; and Ar denotes a phenyl group, optionally having from one to three substituents, each of which is, independently, a halogen or a C1-C4 alkyl, C1-C4 alkoxy, trifluoromethyl, nitro or cyano group, or Ar denotes a naphthyl, pyridyl, quinolinyl or isoquinolinyl group; or a pharmacologically acceptable acid addition salt thereof.
申请公布号 US5001159(A) 申请公布日期 1991.03.19
申请号 US19900517419 申请日期 1990.05.02
申请人 SYNTHELABO 发明人 HOORNAERT, CHRISTIAN;MULLER, JEAN-CLAUDE;BEELEY, NIGEL
分类号 A61K31/165;A61K31/357;A61K31/36;A61K31/435;A61K31/47;A61K31/472;A61K31/535;A61K31/5375;A61K31/54;A61P1/04;A61P9/00;A61P11/08;A61P25/08;C07C67/00;C07C231/00;C07C231/02;C07C231/08;C07C231/12;C07C233/88;C07C235/68;C07D211/14;C07D213/38;C07D213/74;C07D213/82;C07D215/50;C07D217/04;C07D217/26;C07D295/12;C07D295/13;C07D317/58 主分类号 A61K31/165
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