ANALOGIFREMGANGSMAATE FOR FREMSTILLING AV TERAPEUTISK AKTIVE 7BETA-(2-(5-AMINO-1,2,4-TIADIAZOL-3-YL)-2(Z)-SUBSTITUERTOKSYIMINOACETAMIDO)-3-(HETEROCYCLYLMETYL)-3-CEFEM-4-KARBOKSYLSYREDERIVATER.

摘要

A compound of the formula; wherein R<1> is an amino group which may be protected, R<3> is a hydrogen atom or an optionally substituted hydrocarbon residue; Z is S, S -> O, O or CH2, R<4> is a hydrogen atom, methoxy group or formamido group, R<1><3> is a hydrogen atom, methyl group, hydroxyl group or halogen atom and A<(+)> is an optionally substituted imidazolium-1-yl group forming a condensed ring at the 2,3-or 3,4-position or a pharmaceutically acceptable salt or ester thereof is novel and has excellent antibacterial activity.