| 摘要 |
PURPOSE: To provide a confectionery delivery system, comprising an ion exchange resin precoated with lecithin, wax, etc., and a confectionery matrix and capable of effectively masking an unpleasant taste and feeling in the mouth and facilitating the administration. CONSTITUTION: This chewable delivery system comprises (A) an ion exchange resin selected from colestipol or the one, having imidazolium groups as functional groups and precoated with a substance selected from lecithin, a <=4C polyoxyalkylene, a glyceride having <=100 deg.C melting point, a polyalkylene glycol having <=3,700 molecular weight, a synthetic and a natural waxes and a mixture thereof and (B) a confectionery matrix containing about 0.1-5wt.% gelatin, about 0.1-25wt.% humectant substance (glycerol and its 2-7C alkyl ester), a sweetener and about 1-30wt.% water. The ratio of the coating to the active ingredient is preferably within the range of about (1:3) to (1:8). |
