PYRIDINYL-QUINOLONE COMPOUNDS, THEIR PREPARATION AND USE

摘要

PYRIDINYL-QUINOLONE COMPOUNDS, THEIR PREPARATION AND USE Fluorinated 1-cyclopropyl-7-(substituted-pyri-dinyl)-1,4-dihydro-4-oxo-3-quinolinecarboxylic acids of the formula wherein R id hydrogen, R' and R" are hydrogen or fluoro, and Z is 3- or 4-pyridinyl substituted by alkyl groups or substituted alkyl groups, are superior antibacterial agents. They are prepared via a coupling reaction between the corresponding esters (R = alkyl) having a halo group in the 7-position and a substituted (trialkylstannyl)pyridine.