Verfahren zur Herstellung von neuen Phenthiazinamiden

摘要

The invention comprises compounds of the general formula wherein X1 and X2 which may be the same or different represent straight or branched chain alkylene groups having 1 to 3 carbon atoms, R represents an aliphatic, alicyclic, araliphatic, aromatic or heterocyclic acyl radical optionally substituted by halogen atoms or hydroxy, alkoxy, or tertiary amino groups, A and B represent hydrogen or halogen atoms or alkoxy radicals, their non-toxic acid addition salts and quaternary ammonium derivatives and the preparation thereof by either reacting a compound of the formula with a compound Q2-R (III) in which Q1 and Q2 represent groups able to react with each other to form a group of the formula or by esterifying a compound of the general formula or a reactive derivative thereof with a carboxylic acid R-OH, (VI), or a reactive derivative thereof, or by reacting a compound of the formula with a compound of the formula Compounds of Formula V are prepared by reacting a compound of the formula wherein Y represents the acid residue of a reactive ester, with a piperazine derivative 3 - Methoxy - 10 - chloroacetylphenothiazine is prepared from 3-methoxyphenothiazine and chloroacetylchloride. Similarly is prepared 2,3-dimethoxy -10 - chloroacetylphenothiazine, and 3-methoxy- and 2,3-dimethoxy-10-(b -chloro-propionyl) phenothiazine.