POLYPEPTIDE ANALOGS OF APOLIPOPROTEIN E, DIAGNOSTIC SYSTEMS AND METHODS USING THE ANALOGS

摘要

The present invention contemplates a multimeric polypeptide capable of mimicking the ability of apo E to induce differentiated cellular function. The repeating unit of the polypeptide has an amino acid residue sequence corresponding to that represented by the formula LRKLRKRLLRDADDL. Also contemplated is a method for treating hypercholesterolemia in a patient, which method comprises administering to the patient an LDL plasma concentration-reducing amount of the polypeptide. Described as well, is the use of the polypeptide in preparing diagnostic antibodies, and their use in diagnostic systems and methods for detecting apo E antigens in vascular body fluids.