| 摘要 |
Recombinant DNA which codes for a protein with the domains G, K1 and L of t-PA, in which the sequences coding for the domains K2 and F of the wild type t-PA gene or the sequences derived therefrom in the context of the genetic code are completely deleted in accordance with the exact exon/intron limits on the t-PA gene. Process for preparing said recombinant DNA. Vectors which contain said recombinant DNA as well as cells which are transformed with said vectors or said recombinant DNA. Protein with fibrinolytic properties by expression of a DNA sequence according to the invention in suitable host cells, which is composed of the amino acid sequences of the domains G, K1 and L of t-PA in this sequence and is possibly glycosylized. Process for preparing it. Fibrinolytic agent containing a protein according to the invention. |
