| 摘要 |
PURPOSE:To stably produce alpha-keto-beta-methylvaleric acid having high optical purity at a low cost by preparing a cultured cell of a microorganism capable of converting L-isoleucine into an alpha-keto acid and reacting the cell (or its treated product) with L-isoleucine (salt) in an aqueous solution having a specific pH. CONSTITUTION:alpha-Keto-beta-methylvaleric acid suitable as a drug for liver, kidney, etc., can be produced by culturing a microorganism capable of converting L- isoleucine into an alpha-keto acid (preferably a strain belonging to genus Proteus, etc.) and reacting the obtained cell or its treated product with L-isoleucine or its salt in an aqueous solution having a pH of <=7.2. |
