| 摘要 |
<p>Chemical compounds derived from 5-amino-1,2,3,4-tetrahydroacridine (THA) having the general formula (I) wherein R may represent a glycosyl group such as ascorbate, a substituted glycosyl group such as an inosinyle, adenosinyle or guanidosinyle group, a thio-carbamyl group, an adamantyl group, an isatinyl group, an alpha-cetoglutaryl group, H2Z group, wherein Z is a residu of a monoacid or a diacid in ionic form and non covalently bound to the molecule of the compound, said acid being optionally parachlorophenoxy-aceate or pamoate or a hydrogen atom in which case the compound is present in the form of a complex comprising at least a THA molecule associated with at least one molecule selected amongst alpha-adamantane, alpha-amino-adamantane and a nucleoside. These molecules are intended to the treatment of AIDS, degenerative or atrophic diseases, particularly senile dementia of the Alzheimer type, multiple sclerosis or Duchesne myopathy. The ascorbate of THA may be given by parenteral or intraveinous administration.</p> |
