Heterocyclic compounds, processes for producing them and pharmaceutical compositions comprising them.

摘要

Novel heterocyclic compounds capable of lowering the uric acid levels in plasma and urine having the formula (I): <CHEM> wherein R<2> and R<2> are independently hydrogen, lower alkyl, phenyl or substituted phenyl, or R<1> and R<2> may form a four to eight-membered carbon ring together with the carbon atom to which they are attached; R<3>is hydrogen or lower alkyl; R<4> is one or two radicals selected from a group consisting of hydrogen, halogen, nitro, lower alkyl, phenyl, substituted phenyl, -OR<5> and -SO2NR<6>R<6> min ; R<5> is hydrogen, lower alkyl, phenyl-substituted lower alkyl, carboxymethyl or ester thereof, hydroxethyl or ether thereof, or allyl; R<6> and R<6> min are independently hydrogen or lower alkyl; R<7> is hydrogen or a pharmaceutically active ester-forming group; A is a straight or branched hydrocarbon radical having one to five carbon atoms; B is halogen, oxygen, or dithiolane; Y is oxygen, sulfur, nitrogen or substituted nitrogen; Z is oxygen, nitrogen or substituted nitrogen; dotted line represents the presence or absence of a single bond, processes for their production and pharmaceutical compositions comprising them.