发明名称 |
PRODRUG DERIVATIVES OF THYROTROPIN-RELEASING HORMONE (TRH) |
摘要 |
2066449 9103487 PCTABS00003 Compounds of formula (I), wherein R1 is selected from the group consisting of an alkyl group, an aralkyl group, an alkenyl group, a cycloalkyl group, in which the alkyl, aralkyl, alkenyl or cycloalkyl group is unsubstituted or substituted with one or more substituents selected from the group consisting of a halogen atom, e.g. Cl or Br, a hydroxyl group or a straight or branched-chain alkoxy group containing from 1 to 6 carbon atoms; and the pharmaceutically acceptable acid addition salts thereof. Such compounds are prodrugs of TRH and are characterized by having a higher lipophilicity than TRH and possessing a high resistance toward degradation by TRH-inactivating enzymes. Such compounds will after administration be converted into TRH.
|
申请公布号 |
CA2066449(A1) |
申请公布日期 |
1991.03.05 |
申请号 |
CA19902066449 |
申请日期 |
1990.09.03 |
申请人 |
BUNDGAARD, HANS;MOSS, JUDI |
发明人 |
BUNDGAARD, HANS;BUNDGAARD, HANS;MOSS, JUDI;MOSS, JUDI |
分类号 |
A61K38/22;A61K38/00;A61K38/04;A61P5/00;A61P5/12;C07K1/113;C07K5/08;C07K5/097;(IPC1-7):C07K5/097;A61K38/06 |
主分类号 |
A61K38/22 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|