| 摘要 |
<p>PURPOSE:To obtain the subject compound useful as an antiviral agent, etc., in good yield by reacting a uridine derivative with an azidating agent in the presence of phosphines and an azo compound, followed by removing of electron attractive substituent, etc., as necessary. CONSTITUTION:One mol uridine derivative expressed by formula I (R<1> represents H or lower alkyl; R<2> represents electron attractive substituent; R<3> and R<4> represents OH-protecting group) and each 2-5mol phosphines (example; trimethyl phosphine), azo compound (example; dimethyl azodicarboxylate) and azidating agent (example; diphenyl phosphoric acid azide) are subjected to reaction in a solvent such as THF at 0-30 deg.C for 1-10hr under stirring to afford a compound expressed by formula II. Then an electron attractive substituent and an OH- protecting group, for example, are eliminated therefrom and the resultant compound is isolated and purified by recrystallization, etc., to afford the objective compound expressed by formula III (R<2>' represents H or electron attractive substituent group; R<3>' and R<4>' represent H or hydroxy-protecting group).</p> |
