| 摘要 |
PURPOSE:To obtain an artirialization inhibitor containing FR 126756 substance and/or FR 125035 substance and used in treatment for tumor such as solid cancer, chronic articular rheumatism, diabetic retinopathy, retinopathy of immature baby, senile disk-like macular degeneration disease or psoriasis. CONSTITUTION:The aimed inhibitor containing FR 125756 substance expressed by formula I and/or FR 125035 substance expressed by formula II. Dose of the above-mentioned substance is preferably 0.01-100mg/kg wt. day in case of intravenous administration, 0.01-100mg/kg wt. day in case of intramuscular administration and 0.1-100mg/kg wt. day in case of oral administration. The above-mentioned substance is obtained by culturing a yeast strain, e.g. Metarhizium anisopliae F-18302 (FERM P-2424), belonging to the genus Metarhizium and capable of producing a compound expressed by formula I and/or formula II in an aqueous nutritive culture medium under aerobic conditions and subjecting the cultured product to extraction by a proper solvent and chromatography or recrystallization from. a proper solvent. |
